A 54-year-old man with stage 4 chronic kidney disease presents for review. Which one of the following drugs is it most important to avoid?
A. Erythromycin
B. Diazepam
C. Rifampicin
D. Tetracycline
E. Warfarin
Answer :
D. Tetracycline
Discussion:
Drugs to avoid in renal failure include;
antibiotics: tetracycline, nitrofurantoin
NSAIDs
lithium
metformin
Drugs likely to accumulate in chronic kidney disease - need dose adjustment
most antibiotics including penicillins, cephalosporins, vancomycin, gentamicin, streptomycin
digoxin, atenolol
methotrexate
sulphonylureas
furosemide
opioids
Drugs relatively safe - can sometimes use normal dose depending on the degree of chronic kidney disease
antibiotics: erythromycin, rifampicin
diazepam
warfarin
Dearest Esteems,
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