Select an antiviral agent for each patient.
a. Ganciclovir
b. Acyclovir
c. Interferon α
d. Didanosine
e. Ribavirin
f. Amantadine
g. Vidarabine
h. Zalcitabine
A military recruit develops pneumonia secondary to influenza A. Symptoms began 24 h prior to physician visit.
Answer: f. Amantadine
An HIV-positive patient with a CD4 count of 50 complains of the onset of visual blurring; opacity is seen on funduscopic exam.
Answer:a. Ganciclovir
A sexually active young woman has anogenital warts and requests intralesional therapy.
Answer: c. Interferon α
An infant with respiratory syncytial virus infection requires mechanical ventilation.
Answer: e. Ribavirin
Discussion:
- Amantadine has been shown to alter the course of influenza A favorably, particularly when begun within 48 h of the start of symptoms.
- The HIV-positive patient with a low CD4 count and visual blurring has developed cytomegalovirus retinitis. Gancyclovir is the drug of choice (foscarnet has also been used effectively).
- Interferon α has been approved for intralesional therapy of condyloma acuminatum (venereal warts caused by papillomavirus).
- Ribavirin improves mortality in mechanically ventilated infants with RSV infection.
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