A biopsy is taken and reported as follows: Pigment laden macrophages suggestive of melanosis coli
What is the most likely diagnosis?
A. Intestinal melanoma
B. Haemochromatosis
C. Ulcerative colitis
D. Laxative abuse
E. Colorectal cancer
Answer:
D. Laxative abuse
Discussion: Melanosis coli is a disorder of pigmentation of the bowel wall. Histology demonstrates pigment-laden macrophages It is associated with laxative abuse, especially anthraquinone compounds such as senna
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