Which one of these drugs does not prolong the QT interval?
A. Amiodarone
B. Erythromycin
C. Carbemazpine
D. Clozapine
E. Methadone
Answer:
C. Carbemazpine
Discussion: The other drugs mentioned are all well known to cause QT prolongation and should
be avoided in people with long QT syndrome. Sometimes this is difficult and a risk–benefit
decision needs to be made.
Drugs that prolong the QT interval can be remembered with the menomic given below:
Antihistaminics
Anticholinergics
Antiarrythmics (specially Quinidine and Sotalol)
TCAS
Fluoroquinolones
Erythromycin
Other drugs are:
Cloroquine, Mefloquine, Haloperidol, Risperidone, Methadone, and HIV protease Inhibitors.
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