A 23-year-old man with difficult to control epilepsy is reviewed in surgery, four months after a change in his antiepileptic medication. He has remained seizure free but has gained 5 kg in weight since last reviewed. Which one of the following antiepileptic drugs is most associated with weight gain?
A. Ethosuximide
B. Sodium valproate
C. Levetiracetam
D. Carbamazepine
E. Lamotrigine
Answer:
B. Sodium valproate
Discussion: Sodium valproate is used in the management of epilepsy and is first line therapy for generalized seizures. It works by increasing GABA activity.
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