A 54-year-old female with rheumatoid arthritis is noted to have proteinuria on annual review. Which one of the following drugs is most associated with the development of proteinuria?
A. Ciclosporin
B. Gold
C. Methotrexate
D. Infliximab
E. Sulfasalazine
Answer:
B. Gold
Discussion:
Causes Of Nephrotic Syndrome
Primary glomerulonephritis accounts for around 80% of cases
minimal change glomerulonephritis (causes 80% in children, 30% in adults)
membranous glomerulonephritis
focal segmental glomerulosclerosis
membranoproliferative glomerulonephritis
Systemic disease (about 20%)
diabetes mellitus
systemic lupus erythematosus
amyloidosis
Drugs
gold (sodium aurothiomalate),
penicillamine
Others
congenital
neoplasia: carcinoma, lymphoma, leukaemia, myeloma
infection: bacterial endocarditis, hepatitis B, malaria
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