A 45 year old woman is brought to the emergency department with seizures. Her daughter informed the doctor that she has been on antituberculosis therapy for last 2 months, There was no previous history of seizures or epilepsy.
The best therapy for seizures secondary to isoniazid ingestion is:
A) Lorazepam.
B) Phenytoin.
C) Pyridoxine.
D) Thiamine.
E) Phenobarbital.
Answer And Discussion
The correct answer is “C.”Pyridoxine
Isoniazid is a B-6 antagonist. Thus, pyridoxine (in massive doses!!) is the drug of choice in isoniazid-induced seizures. These seizures are often resistant to conventional therapy.
Look for this type of overdose in patients who are being treated for tuberculosis (either active or latent disease).
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