Case Scenario:
A 42-year-old white man is seen in the ER with a chief complaint of shortness of breath that has lasted for 1 week. He reports having had a viral syndrome approximately 3 weeks before admission. Subsequently, he noted the development of lower extremity edema, a 15-lb weight gain, dyspnea on
exertion, and orthopnea. Currently he complains of dyspnea at rest.
Physical examination reveals an irregularly irregular heart rate of 130 per minute. His blood pressure is 90/60 mm Hg, and his respiratory rate is 22 per minute.
Examination of the jugular venous pressure demonstrates a mean pressure of 12 to 14 cm of water with a prominent V wave.
Lung examination reveals bibasilar dullness with rales extending one fourth of the way up from the basal lung fields bilaterally.
Cardiac examination findings are significant for a diffuse point of maximal impulse, which is displaced to the anterior axillary line. The S1 and S2 are of variable intensity, and a prominent S3 gallop over the displaced cardiac apex is appreciated. There is a grade 2/6 holosystolic murmur that is heard best at the cardiac apex, with prominent radiation to the axilla and no change w ith respiration. On examination of the abdomen, an enlarged, tender liver is found.
The extremities are cool and exhibit 2+ pitting edema.
The ECG show s atrial fibrillation with nonspecific ST-T–w ave changes, a left bundle branch block (LBBB) and occasional ventricular premature beats.
Arterial blood gas measurements performed with the patient on 4 L of oxygen per minute by nasal cannula reveal a pH of 7.46, a PO2 of 52 mm Hg, a PCO2 of 32 mm Hg, and a bicarbonate (HCO3) concentration of 26 mmol/L.
Answer the following questions:
1. Does this patient have left, right, or biventricular failure?
2. An S3 is heard, but no S4. Why?
3. What chest radiographic findings would you expect to see in this patient?
4. What neurohormonal mechanisms are likely to be activated in this patient?
5. What diagnostic tests should be performed?
6. What treatment options would likely be beneficial in this patient?
7. Is it possible that the ventricular function w ill improve with medical therapy?
Answers: